Microscopic Polyangiitis Insights

AAV Relapse Risk Varies by Type

February 06, 2025 • Estimated Reading Time: 1 minute

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In their case report, Escoda et al. (2025) discuss a rare occurrence where granulomatosis with polyangiitis (GPA), a type of small vessel vasculitis, was found alongside an often underdiagnosed spondyloarthritis. The patient presented with multisystemic disease, which is common in antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) and can lead to severe organ damage. The study highlights that while GPA and microscopic polyangiitis typically affect respiratory tracts and kidneys, they can potentially impact any organ.

Furthermore, the case report notes that osteoarticular involvement in AAV is usually generalized and not specific, often manifesting as myalgia, arthralgia, or arthritis of peripheral joints. The patient in question responded well to treatment with rituximab, an indication that this medication can be effective in managing such complex presentations of AAV.

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February is here and the countdown to Rare Disease Day 2025 has begun!

Vasculitis is a group of rare conditions, there are many different types.

Vasculitis is inflammation in the walls of the blood vessels and can affect any size and type of blood vessel (arteries and veins), anywhere in the body. Vasculitis can be severe, even fatal if not diagnosed early and treated correctly.