Microscopic Polyangiitis Insights

This week's must-know community updates, latest research & events

March 19, 2025 • Estimated Reading Time: 1 minute

Latest Research

The mini-review in Rheumatology (2025) examines the link between interstitial lung disease (ILD), antineutrophil cystoplasmic antibodies (ANCA), and microscopic polyangiitis (MPA). It delves into the radiographic and histopathologic evidence, as well as genetic factors that may contribute to the development of these conditions. The review suggests a possible pathogenesis for how ILD and MPO-ANCA are related to MPA.

Furthermore, the article outlines a practical approach for clinicians treating patients who either present with ILD and test positive for ANCA or have MPA with ILD. The recommended treatment strategies are informed by the latest guidelines for managing both ILD and ANCA-associated vasculitis. This approach aims to provide a clear direction for healthcare providers in the diagnosis and management of these complex conditions.

Clinical Trials

This is a list of upcoming or ongoing clinical trials that are actively recruiting and have been listed or updated in the last two weeks:

Iptacopan in Patients With ANCA Associated Vasculitis

An Open-label Study of Povetacicept in Autoantibody-Associated Glomerular Diseases

View the full list of clinical trials →

Community News

Vasculitis FoundationMar 14, 2025

"Hi. I'm Lexi from Granite Bay, California. In June of 2024, red dots popped up on my feet and ankles. By July, the dots had spread up my legs and blistered, it was the most painful experience of my life. The ulcers lasted for months and left me scarred. After multiple misdiagnoses, hospital visits, and biopsies, my mystery disease was finally revealed- IgA Vasculitis. Luckily, Dr. Kermani at UCLA gave me the right medication and my quality of life back. I still have ups and downs but my condition has improved.

My parents and friends were my lifeline during this turbulent time. My mom and stepdad drove 8 hours to my first specialist appointment in LA from Sacramento. I wouldn’t be where I am now without their love and support.

It's isolating and terrifying having a rare disease but you have to be brave and be your biggest advocate. Despite our rarity, we deserve answers and the best care possible."

Vasculitis FoundationMar 16, 2025

"Hello! I am Sirat, a 19-year-old from Lucknow, India. I was diagnosed with ovarian torsion after severe abdominal pain and vomiting. In May 2024, I had an operation and was sent back home. A week later, I started vomiting again. I didn't eat anything for a week, I had purpura all over my legs, and my old hospital couldn’t diagnose me. They took a skin biopsy and sent me home.

My condition grew worse, so we went to another hospital where they diagnosed it as IGA vasculitis. I was shattered to see on Google that it has no cure and that I have to live with it for the rest of my life. My protein-urine was 2 grams+ in 24 hours so they told me to undergo a kidney biopsy. I was crying constantly. A kidney biopsy was performed and a hematoma formed as a result. I was in shock and overwhelmed by how things were going against me. But, at that point, things finally changed! The purpura vanished. I started eating. My hematoma was reduced, and they gave me steroids for 6 months. I am off steroids now 🧿

My reports are positive and I am doing better. I went back to college; when I was going into OT for a kidney biopsy my first-year results came and I secured 1st position!

Life doesn’t end with a diagnosis. I love my parents and everyone who supported me when I went through this crucial time. I wish only for happiness and strength for the people who deal with this!! We are strong."

Vasculitis FoundationMar 13, 2025

March is Autoimmune Disease Awareness Month. Because vasculitis is a rare autoimmune disease it’s important for patients to have a basic understanding of autoimmunity.

In this short video, Dr. Phil Seo, Director of the Johns Hopkins Vasculitis Center, presents an explanation about autoimmuity with the help of the popular Minions cartoon characters. His presentation is clever, educational, and tells you what you need to know about the biology of autoimmunity. View video clip here: